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細(xì)胞系

細(xì)胞庫(kù)

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科研抗體

AXIN2抗原（重組蛋白）

規(guī)格：

數(shù)量：

購(gòu)買數(shù)量

價(jià)格：￥

中文名稱：AXIN2抗原（重組蛋白）

英文名稱： AXIN2 Antigen (Recombinant Protein)

別名：AXIL; ODCRCS

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to N terminal 160 amino acids of human AXIN2

技術(shù)規(guī)格：

Full name:	axin 2
Synonyms:	AXIL; ODCRCS
Swissprot:	Q9Y2T1
Gene Accession:	NP_004646
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

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