ELISA試劑盒

PCR試劑盒

生化試劑盒

細(xì)胞系

細(xì)胞庫(kù)

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專(zhuān)用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

CDKN2AIP抗原（重組蛋白）

規(guī)格：

數(shù)量：

購(gòu)買(mǎi)數(shù)量

價(jià)格：￥

中文名稱(chēng)： CDKN2AIP抗原（重組蛋白）

英文名稱(chēng)： CDKN2AIP Antigen (Recombinant Protein)

別名： CARF

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別：抗原

概述

Fusion protein corresponding to a region derived from 175-425 amino acids of human CDKN2AIP

技術(shù)規(guī)格

Full name:	CDKN2A interacting protein
Synonyms:	CARF
Swissprot:	Q9NXV6
Gene Accession:	BC022270
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

ELISA試劑盒

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