中文名稱: RIPK1 抗原(重組蛋白)
英文名稱: RIPK1 Antigen (Recombinant Protein)
別 名: receptor interacting serine/threonine kinase 1; RIP; RIP1; RIP-1
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別:抗原
技術(shù)規(guī)格
Full name: |
receptor interacting serine/threonine kinase 1 |
Synonyms: |
RIP; RIP1; RIP-1 |
Swissprot: |
Q13546 |
Gene Accession: |
BC126254 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. |