ELISA試劑盒

PCR試劑盒

生化試劑盒

細胞系

細胞庫

基礎培養(yǎng)基

完全培養(yǎng)基

原代細胞

細胞專用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

IRAK1BP1抗原（重組蛋白）

規(guī)格：

數(shù)量：

購買數(shù)量

價格：￥

中文名稱： IRAK1BP1抗原（重組蛋白）

英文名稱： IRAK1BP1 Antigen (Recombinant Protein)

別名： AIP70; SIMPL

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Full length fusion protein

技術規(guī)格

Full name:	interleukin-1 receptor-associated kinase 1 binding protein 1
Synonyms:	AIP70; SIMPL
Swissprot:	Q5VVH5
Gene Accession:	BC112253
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

ELISA試劑盒

PCR試劑盒