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  • DCPS 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW16488
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：60
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中文名稱： DCPS 抗原（重組蛋白）

英文名稱： DCPS Antigen (Recombinant Protein)

別     名： decapping enzyme, scavenger; ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015

儲     存： 冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to a region derived from 2-337 amino acids of human DCPS

技術(shù)規(guī)格

Full name:

decapping enzyme, scavenger

Synonyms:

ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015

Swissprot:

Q96C86

Gene Accession:

BC014532

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.