Background: |
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. |
Applications: |
WB |
Name of antibody: |
CHFR |
Immunogen: |
Synthesized peptide derived from Internal of human CHFR. |
Full name: |
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase |
Synonyms: |
RNF116; RNF196 |
SwissProt: |
Q96EP1 |
WB Predicted band size: |
73 kDa |
WB Positive control: |
Jurkat cells lysate |
WB Recommended dilution: |
500-3000 |