Fusion protein corresponding to C terminal 77 amino acids of human FUS |
技術(shù)規(guī)格
Full name: |
FUS RNA binding protein |
Synonyms: |
TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2 |
Swissprot: |
P35637 |
Gene Accession: |
BC000402 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. |