中文名稱: UMPS 抗原(重組蛋白)
英文名稱: UMPS Antigen (Recombinant Protein)
別 名: uridine monophosphate synthetase; OPRT
相關(guān)類別:抗原
儲 存: 冷凍(-20℃)
概 述
Full name: |
uridine monophosphate synthetase |
Synonyms: |
OPRT |
Swissprot: |
P11172 |
Gene Accession: |
BC000364 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. |