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中文名稱：兔抗CD5多克隆抗體
英文名稱： Anti-CD5 rabbit polyclonal antibody
別 名： CD5 molecule; T1; LEU1
相關(guān)類別： 一抗
抗 原： CD5
儲(chǔ) 存： 冷凍（-20℃）
宿 主 ： Rabbit
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56. In vitro studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CD5 |
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Immunogen: |
Synthetic peptide of human CD5 |
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Full name: |
CD5 molecule |
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Synonyms: |
T1; LEU1 |
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SwissProt: |
P06127 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
30-150 |
