購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： 兔抗VWA5A多克隆抗體
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Background: |
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
VWA5A |
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Immunogen: |
Fusion protein of human VWA5A |
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Full name: |
von Willebrand factor A domain containing 5A |
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Synonyms： |
BCSC1; BCSC-1; LOH11CR2A |
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SwissProt: |
O00534 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human cervical cancer and human lung cancer |
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IHC Recommend dilution: |
100-300 |
