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中文名稱： 兔抗PTEN (Phospho-Ser380/Thr382/Thr383)多克隆抗體
英文名稱： Anti-PTEN (Phospho-Ser380/Thr382/Thr383) rabbit polyclonal antibody
別 名： BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
抗 原： PTEN (Phospho-Ser380/Thr382/Thr383)
技術(shù)規(guī)格
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Background: |
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
PTEN (Phospho-Ser380/Thr382/Thr383) |
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Immunogen: |
Synthetic peptide of human PTEN (Phospho-Ser380/Thr382/Thr383) |
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Full name: |
phosphatase and tensin homolog (Phospho-Ser380/Thr382/Thr383) |
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Synonyms： |
BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del |
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SwissProt: |
P60484 |
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IHC positive control: |
Human breast carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
54 kDa |
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WB Positive control: |
Hela cells |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
