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021-54845833/15800441009
中文名稱：兔抗SELENON多克隆抗體
英文名稱： Anti-SELENON rabbit polyclonal antibody
別 名： selenoprotein N; RSS; CFTD; SELN; MDRS1; RSMD1; SE
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： SELENON
反應(yīng)種屬： Human
標(biāo)記物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016] |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
SELENON |
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Immunogen: |
Synthetic peptide of human SELENON |
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Full name: |
selenoprotein N |
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Synonyms: |
RSS; CFTD; SELN; MDRS1; RSMD1; SEPN1 |
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SwissProt: |
Q9NZV5 |
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IHC positive control: |
Human thyroid cancer and Human tonsil |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
66 kDa |
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WB Positive control: |
Human placenta tissue |
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WB Recommended dilution: |
500-2000 |
