Background: |
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. |
Applications: |
ELISA, IHC |
Name of antibody: |
ERVW-1 |
Immunogen: |
Synthetic peptide of human ERVW-1 |
Full name: |
endogenous retrovirus group W, member 1 |
Synonyms: |
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
SwissProt: |
Q9UQF0 |
ELISA Recommended dilution: |
2000-5000 |
IHC positive control: |
Human esophagus cancer |
IHC Recommend dilution: |
25-100 |