中文名稱: IL6ST 抗原(重組蛋白)
英文名稱: IL6ST Antigen (Recombinant Protein)
別 名: interleukin 6 signal transducer; CD130; GP130; CDW130; IL-6RB
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
Fusion protein corresponding to a region derived from 670-918 amino acids of human IL6ST |
技術(shù)規(guī)格
Full name: |
interleukin 6 signal transducer
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Synonyms: |
CD130; GP130; CDW130; IL-6RB |
Swissprot: |
P40189 |
Gene Accession: |
BC117402 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
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