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  • 兔抗MAPK8 MAPK9 MAPK10(phospho-Thr183 Tyr185)多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17427
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：80
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中文名稱： 兔抗MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)多克隆抗體


英文名稱： Anti-MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) rabbit polyclonal antibody


別       名： Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46


相關(guān)類別： 一抗


儲(chǔ)       存： 冷凍（-20℃） 避光


宿       主： Rabbit


抗     原： MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)


反應(yīng)種屬： Human, Mouse, Rat

標(biāo)  記  物： Unconjugate


克隆類型： rabbit polyclonal


技術(shù)規(guī)格

Background:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Applications:

WB, IF

Name of antibody:

MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Immunogen:

Synthetic peptide of human MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Full name:

MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Synonyms：

Stress-activated protein kinase JNK1 ; c-Jun N-terminal kinase 1; JNK-46

SwissProt:

P45983/P45984/P53779

WB Predicted band size:

46 kDa; 54 kDa

WB Positive control:

C6 cells treated with anisomycin

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200