購物車
幫助
021-54845833/15800441009
中文名稱：BCCIP抗原（重組蛋白）
英文名稱： BCCIP Antigen (Recombinant Protein)
別 名： TOK1; TOK-1
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 59-167 amino acids of human BCCIP |
|
Full name: |
BRCA2 and CDKN1A interacting protein |
|
Synonyms: |
TOK1; TOK-1 |
|
Swissprot: |
Q9P287 |
|
Gene Accession: |
BC009771 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
