技術(shù)規(guī)格
Background: |
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. |
Applications: |
WB |
Name of antibody: |
RCAN1 |
Immunogen: |
Fusion protein of human RCAN1 |
Full name: |
regulator of calcineurin 1 |
Synonyms: |
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78 |
SwissProt: |
P53805 |
WB Predicted band size: |
28 KD |
WB Positive control: |
Jurkat cell, Mouse brain tissue lysates |
WB Recommended dilution: |
500-2000 |